Neutrophilic inflammation in asthma and defective epithelial translational control
نویسندگان
چکیده
منابع مشابه
Neutrophilic inflammation in childhood asthma
A lthough asthma has its highest prevalence in childhood, it is generally less severe than in adolescents and adults. Whether the high population prevalence is because symptoms are more noticed by parents or whether the more physically active lifestyle and natural inquisitiveness of children, particularly young children, unmasks bronchial hyperresponsiveness and related symptoms remains elusive...
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STUDY OBJECTIVES Airway neutrophil levels are increased in patients with severe asthma and during asthma exacerbations. Long-acting beta2-agonists (LABAs), such as formoterol, reduce the number of asthma exacerbations. While beta2-agonists may affect neutrophil function in vitro, it is uncertain whether they have effects on neutrophilic inflammation in asthmatic patients in vivo. DESIGN In a ...
متن کاملNeutrophilic inflammation in severe persistent asthma.
Airway inflammation in severe asthma is not well characterized but may involve neutrophils. We have compared induced sputum profiles in patients with asthma of varying severity and normal control subjects. We have also measured exhaled nitric oxide (NO) as a noninvasive marker of inflammation. Asthma severity was based on clinical features before treatment and the minimum medication required to...
متن کاملCellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma
Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic inflammatory patterns. Eosinophilic inflammation can be associated with the whole spectrum of asthma severity, ranging from mild-to-moderate to severe uncontrolled disease, whereas neutrophilic inflammation occurs most...
متن کاملClarithromycin targets neutrophilic airway inflammation in refractory asthma.
RATIONALE Patients with refractory asthma have persistent symptoms despite maximal treatment with inhaled corticosteroids and long-acting bronchodilators. The availability of add-on therapies is limited, and effective add-on therapies that target noneosinophilic airway inflammation are needed. Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, ke...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2019
ISSN: 0903-1936,1399-3003
DOI: 10.1183/13993003.00547-2019